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Lichtig, H., Artamonov, A., Polevoy, H., Reid, C., Bielas, S. and Frank, D. (2020) Modeling Bainbridge-Ropers Syndrome in Xenopus laevis embryos.  Front Physiol. doi:10.3389/fphys.2020.00075


Polevoy, H., H., Gutkovich, Y.E., Michaelov, A., Volovik, Y. Elkouby, Y.M. and Frank, D. (2019) New roles for Wnt and BMP signaling in neural anteroposterior patterning. EMBO Rep. 20, e45842. DOI 10.15252/embr.201845842                                                                                                                                     This paper highlighted in EMBO Reports News and Reviews: Transformation of a neural activation and patterning model. Al Anber A, Martin BL EMBO Rep. (2019) 20, e48060. 10.15252/embr.201948060


Frank, D* and Sela-Donenfeld, D.* (2019) Hindbrain induction during early vertebrate development. Cell Mol Life Sci. 76, 941-960. doi: 10.1007/s00018-018-2974-x. Epub 2018 Dec 5. *co-corresponding authors.


Lichtig, H., Cohen, Y., Bin-Nun, N., Golubkov, V.  and Frank, D. (2019) PTK7 proteolytic fragment proteins function during early Xenopus development.  Dev. Biol. 453, 48-55.


Sela-Donenfeld, D.* and Frank, D.* (2017) A Brief History of Developmental Biology in Israel. Int. J. Dev. Biol. 61, 115-120. *co-corresponding authors.


Polevoy, H., Malyarova, A., Fonar, Y., Elias, S. and Frank, D. (2017) FoxD1 protein interacts with Wnt and BMP signaling to differentially pattern mesoderm and neural tissue. Int. J. Dev. Biol. 61, 293-302.


Hudry, B., Thomas-Chollier, M., Volovik, Y., Frank, D., Technau, U. and Merabet, S. (2014) A Hox-TALE molecular interaction network predates axis formation and bilateral symmetry in metazoans. eLIFE 2014, Mar 18; 3e01939. DOI: 10.7554. 1-24. 

Frankenberg, S.F., Frank, D., Harland, R.M., Johnson, A.D., Nichols. J., Niwa, H., Schöler, H., Tanaka, E., Wylie, C., and Brickman, J.M. (2014) The POU-er of gene nomenclature. Spotlight Correspondence. Development 141, 2921-2923.


Volodarsky, M., Lichtig, H., Leibson, T., Sadaka, Y. Kadir, R.,  Liani-Leibson, K.,    Gradstein, L., H., Shaco-Levy, R., Shorer, Z., Frank, D. and Birk, O.S. (2015)  CDC174, a novel component of the exon junction complex whose mutation underlies a syndrome of hypotonia and psychomotor developmental delay. Hum Mol Genet. 24, 6485-6491.

Bin-Nun, N., Lichtig, H., Malyarova, A., Levy, M., Elias, S. and Frank, D. (2014) PTK7 modulates Wnt signaling activity via LRP6. Development 141, 410-421.



Schulte, D. and Frank, D. (2014)  Review: TALE transcription factors during early development of the vertebrate brain and eye.  Dev. Dyn. 243, 99-116.



Elkouby, Y.M., Polevoy, H., Gutkovich, Y.E., Michaelov, A. and Frank, D. (2012) A hindbrain-repressive Wnt3a/Meis3/Tsh1 circuit promotes neuronal differentiation and coordinates tissue maturation. Development 139, 1487-1497.


Fonar, Y., Gutkovich, Y.E., Root, H., Malyarova, A., Aamar, E., Golubovskaya, V.M., Elias, S., Elkouby, Y.M. and Frank, D. (2011) Focal Adhesion Kinase protein regulates Wnt3a gene expression to control cell fate specification in the developing neural plate. Mol. Biol. Cell 22, 2409-2421. Faculty of 1000 (F1000) Ranked

Fonar, Y. and Frank, D. (2011) Review: FAK and WNT Signaling: The Meeting of Two Pathways in Cancer and Development.  Anticancer Agents Med Chem. 11, 600-606.


Gutkovich, Y.E., Ofir, R., Elkouby, Y.M., Dibner, C., Gefen, A., Elias, S. and Frank, D. (2010) Xenopus Meis3 protein lies at a nexus downstream to Zic1 and Pax3 proteins, regulating multiple cell-fates during early nervous system development. Dev. Biol. 338, 50-62. 

Elkouby, Y.M., Elias, S., Casey, E.M., Blythe, S.A., Tsabar, N., Klein, P.S., Root, H., Liu, K.J., and Frank, D. (2010)  Mesodermal Wnt signaling organizes the neural plate via Meis3. Development 137, 1531-1541.

Elkouby, Y.M. and Frank, D. (2010) Review/Minibook: Wnt/beta-catenin-signaling in vertebrate posterior neural development. Colloquium Series on Developmental Biology, (ed. D.S. Kessler), eBook 4. pp. 1-79. San Rafael, CA, USA.Morgan and Claypool Life Sciences.


Snir, M., Ofir, R., Elias, S. and Frank, D. (2006) Xenopus laevis POU91 protein, an Oct3/4 homologue, regulates competence transitions from mesoderm to neural cell fates. EMBO J. 25 3664-3674.


Borchers, A., Fonar, Y., Frank, D. and Baker, J.C. (2006) XNF-ATc3 affects neural convergent extension. Development 133, 1745-1755.


Keren, A., Bengal, E.* and Frank, D.* (2005) p38 MAP kinase regulates the expression of XMyf5 and affects distinct myogenic programs during Xenopus development. Dev. Biol. 288, 73-86, *co-corresponding authors.



​Aamar, E. and Frank, D. (2004) Xenopus Meis3 protein forms a hindbrain- inducing center by activating FGF/MAP kinase and PCP pathways. Development 131, 153-163.

Dibner, C., Elias, S., Ofir, R., Souopgui, J., Kolm, P., Sive, H., Pieler, T. and Frank, D. (2004) The Meis3 Protein and Retinoid Signaling Interact to Pattern the Xenopus Hindbrain. Dev. Biol. 271, 76-87.


​Dibner, C., Elias, S. and Frank, D. (2001) XMeis3 protein activity is required for proper hindbrain patterning in Xenopus laevis embryos. Development 128, 3415-3426.

Inbal, A., Halachmi, N., Dibner, C., Frank, D. and Salzberg, A. (2001) Genetic Evidence for the Transcriptional-Activating Function of Homothorax During Adult Fly Development. Development 128, 3405-3413.  

Zetser, A., Frank, D.* and Bengal, E.* MAP kinase converts MyoD into an instructive muscle differentiation factor in Xenopus. (2001) Dev. Biol 240, 168-181, *co-corresponding authors.

Ribisi, S. Jr., Mariani, F.V., Aamar, E., Lamb, T., Frank, D. and Harland, R.M. (2000) Ras-mediated FGF signaling is required for the formation of posterior but not anterior neural tissue in Xenopus laevis. Dev. Biol. 227, 183-196.


Salzberg, A., Elias, S., Nachaliel, N., Bonstein, L., Henig, C. and Frank, D. (1999) A Meis family protein caudalizes neural cell fates in Xenopus. Mech. Dev. 80, 3-13.


Bonstein, L., Elias, S. and Frank, D. (1998) Paraxial fated mesoderm is required for neural crest induction in Xenopus embryos. Dev. Biol. 193, 156-168.

Henig, C., Elias, S. and Frank, D. (1998) A POU protein regulates mesoderm competence to FGF in Xenopus. Mech. Dev. 71, 131-142.

Nachaliel, N., Re'em - Kalma, Y., Eshed, O., Elias, S. and Frank, D. (1998) BMP regulates vegetal pole induction centres in early Xenopus development. Genes to Cells 3, 649-658.


Re'em, Y., Lamb, T. and Frank, D. (1995) Competition between noggin and bone morphogenetic protein-4 activities may regulate dorsalization during Xenopus development. Proc. Natl. Acad. Sci. 92, 12141-12145.

























































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